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Is it possible to separate enantiomers with a C18 HPLC column?

Generally it is not possible to separate enantiomers with a common C18 column. A simple way to separate enantiomers is to use a chiral column. However by the addition of an enantiomer (e.g. tartaric acid) to the mobile phase or by derivatisation of the sample, it is possible to achieve a chiral separation on a non-chiral column.

Cis-trans isomers are well separated on columns with a high carbon load, like KNAUER Eurospher II C18 P.

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