IJM NanoScaler: a benchtop system for lipid nanoparticle formulation Contact us
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Article No.: A48040
Articlename: IJM NanoScaler

IJM NanoScaler

The IJM NanoScaler: a benchtop system for lipid nanoparticle formulation (LNP, microemulsions, etc.)

The IJM NanoScaler is made with research and development and lab-scale production in mind.

Equipped with our proven Impingement Jets Mixing (IJM) technology for the production of lipid nanoparticles the NanoScaler allows researchers to determine the optimum encapsulation conditions for their mRNA based therapy before scaling up the process to run on a larger GMP-compliant IJM NanoProducer unit.

The NanoScaler is made for low sample consumption so as not to waste valuable API. Its small footprint means it can comfortably sit on the benchtop of a research and development lab. The system comes with five different KNAUER Impingement Jets Mixers to help researchers determine which conditions result in the optimum level of nucleotide encapsulation. In addition researchers can use their own custom mixing unit and benefit from the flexibility of the system set-up.

The encapsulation process can be remotely controlled by software; ran from a conventional PC or laptop, or even a tablet.

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your IJM NanoScaler very easily and build up the system you need.

  • A71103 Lipid Loop: Additional injection valve for lipids
  • A71114 3x Flowmeter: Flowrate monitoring of all pumps

Key Features

Technical Data

Impingement Jets Mixing System Details

Fields of applications LNP Research and Development (R&D)
Number of impingement jets mixers 5
Number of pumps 3
Number of valves 2
Process connection inlet 1/8“ OD, 2.1 mm, ID FEP tubing (UNF 1/4-28 thread, flat bottom)
Process connection outlet 1/16“ OD, 0.5 mm, ID PEEK tubing (UNF 10-32, thread coned)
Volumetric flow rate (L/min) up to 0.05 liter/min
Volumetric flow rate (L/hour) 3
Maximum operation pressure 140 bar (2030 psi)
Liquid temperature range 4−60 °C (39.2−140 °F)
Wetted materials Titanium, stainless steel, PEEK, GFP (graphite fiber reinforced PTFE), FFKM, PTFE, FEP, UHMW PE, ruby, aluminum oxide (Al2O3), sapphire, Zirconium oxide, POM, Tefzel® (ETFC)
Software CDS, 21 CFR part 11 compliant
Ambient conditions Temperature range: 4–40 °C; 39.2–104 °F; humidity: below 90 % (non condensing)

Documents and more information

Certified Quality 

KNAUER is known for the quality of its products and has been certified several times. We produce high-tech laboratory instruments for research, routine analysis and production.
See all Quality certificates

In addition, we have extended documentation about all our products, including CE Declarations of Conformity.
See all CE Declarations of conformity

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