Impingement Jets Mixing Skids for high flow production of nanoparticles (LNP, microemulsions, etc.) Contact us
print page
Article No.: A48039X97
Articlename: IJM DuoCore NanoProducer

IJM DuoCore NanoProducer

IJM DuoCore NanoProducer (Impingement jets mixing technology) for the high flow production of lipid nanoparticles (LNP, microemulsions, etc.)

The IJM DuoCore NanoProducer for high flow production of nanoparticles (LNP, microemulsions, etc.) contains two parallel mixing units. Each unit consists of four pumps enabling all the steps from predilution of the concentrated Active Pharmaceutical Ingredient (API), Impingement Jets Mixing of lipid and API phase, and finally the quenching of the nanoparticle solution. Furthermore, each unit is equipped with four flowmeters for flow monitoring, one jets mixer, and two mixers for predilution and quenching. 


Our CDS software provides an intuitive and easy operating of the IJM-SKID. The system visualization offers a graphical representation and allows easy handling of the complex flow processes. Additionally, each device that is displayed in the fluidic scheme can be manually controlled. You have the opportunity to optimize, change and adapt your conditions also during the run. The software complies with 21 CFR Part 11.

All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.


The IIJM DuoCore NanoProducer for high flow production of nanoparticles (LNP, microemulsions, etc.) consisting of:

  • 8 KNAUER high-pressure dosing pumps 80P
  • 8 Coriolis flow meters
  • 2 Impingement jet mixers
  • 4 Mixers
  • 2 8-port multiposition Valve
  • Inlet for Lipid and mRNA (Sanitary Clamp Connector)
  • Inlet for citrate buffer (Sanitary Clamp Connector)
  • An outlet for LNP solution (Sanitary Clamp Connector)
  • Internal piping
  • Frame (Stainless Steel system 1.4301; 1000 x 1310 x 800 mm (WxHxD))
  • CDS software, 21 CFR part 11 compliant
  • Chromatography workstation with 27" monitor

In addition, we offer for our customers:

  • Material Documentation of wetted surfaces 
  • Customer Service before, during, and after the setup
  • Capillary customization and labeling
  • FAT (Factory Acceptance Test at KNAUER Berlin)
  • SAT (Site Acceptance Test at customer site)


The skid-based NanoProducer units like the one shown require sophisticated craftsmenship and know-how. That's why they are exclusively designed, certified & distributed only directly by KNAUER Germany. The same applies for the offered additional services.



Key Features

Technical Data

Impingement Jets Mixing System Details

Fields of applications LNP production
Number of impingement jets mixers 4
Number of pumps 8
Number of flow meters 8
Number of valves 2
Process connection inlet 3/8" and 1/4" barbed fitting (6 Inlets) - different connections on request
Process connection outlet 1/4" barbed fitting (2 Outlets) - different connections on request.
Volumetric flow rate (L/min) up to 2 liter/min
Volumetric flow rate (L/hour) up to 120 liter/h
Maximum operation pressure 100 bar
Liquid temperature range 4−60 °C (39.2−140 °F)
Wetted materials stainless steel, PEEK, Titanium, FFKM, PTFE, GFP (graphite fiber reinforced PTFE), aluminum oxide (Al2O3), ruby, sapphire
Software CDS, 21 CFR part 11 compliant
Interfaces Pump: LAN, RS-232, pin header connectors;
Flow meter: RS-232 + FLOWBUS;
Valve drive: LAN
Power supply Pump: 100–240 V, 50–60 Hz;
Flow meter: +15…24 V DC,
Valve drive: 24 V DC
Maximum power consumption Values per device
Pump: maximum 320 W;
Flow meter: 3 W ;
Valve drive: 65 W
Ambient conditions Temperature range: 4–40 °C; 39.2–104 °F; below 90 % humidity (non condensing)
Dimensions 1000 x 1290 x 800 mm (WxHxD)
Weight ~ 250kg
API-predilution and quenching Yes
GMP-ready documentation Yes
Factory acceptance test Yes
Site acceptance test Yes
Purchase order lead time about 3 months
Disclaimer Depending on the process the end user must consider the legal situation of patents and intellectual property. KNAUER is designing the customized hardware solution on customers request

Documents and more information

Certified Quality 

KNAUER is known for the quality of its products and has been certified several times. We produce high-tech laboratory instruments for research, routine analysis and production.
See all Quality certificates

In addition, we have extended documentation about all our products, including CE Declarations of Conformity.
See all CE Declarations of conformity

Innovation and quality - since 1962. Made in Germany.

Do you need more details or a quote?

We are happy to help you

+49 30 809727-0

Mo – Fr
07:00 – 17:00 CE(S)T


24 / 7

Technical data or prices are subject to change without notice. Prices may vary by country and do not include taxes, customs duties or delivery. All trademarks are the property of their respective owners.Our general terms and conditions apply: www.knauer.net/terms

Follow us on: