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Does a back pressure regulator affect the pressure limit of the column?

Back pressure and column pressure limits

By applying an additional pressure behind the column only the column hardware is affected in contrast the column bed, which is not affected.

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Based in Berlin, KNAUER is a medium-sized company that has been serving the sciences since 1962. We are a developer and manufacturer of scientific instruments of superior quality for liquid chromatography (LC), liquid dosing and other laboratory tasks. The product range includes systems, engineering solutions and components for:

Analytical HPLC / UHPLC
Preparative HPLC
Fast protein liquid chromatography (FPLC)
Multi-column Chromatography / SMB
High-pressure dosing solutions
Lipid nanoparticle (LNP) production and research
Osmometry

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