Impingement Jets Mixing Skids for high flow production of nanoparticles (LNP, microemulsions, etc.)

Customized impingement jets mixing skid for large production scale

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Article No.: IJM-SKID-8
Articlename: IJM-Skid - Customized Large Production Scale Unit

Customized impingement jets mixing skid for large production scale

Production-scale Impingement Jets Mixing (IJM) Skid for the high flow production of lipid nanoparticles (LNP, microemulsions, etc.)

The Impingement Jets Mixing (IJM) Large Production Scale Units for high flow production of nanoparticles (LNP, microemulsions, etc.) can be configured with up to eight parallel mixing units depending on customer requirements. Each unit consists of two pumps to deliver lipid and API streams, two flowmeters for flow control, and one jet mixer.

Depending on the configuration, the predilution of the API and quenching can be performed for the combined flow of all units in one process step outside the Impingement Jets Mixing (IJM) Production Scale Unit.

The number of parallel units depends on the application. Also, the number of pumps, flowmeters, jets mixers, and pipes can be adapted to the required conditions and scale. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.


The Impingement Jets Mixing (IJM) Large Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) consisting of:

  • up to 16 KNAUER high-pressure dosing pumps 80P
  • up to 16 Coriolis flow meters
  • up to 8 KNAUER IJM mixers
  • Inlet manifolds for lipid/ethanol mixture and mRNA/buffer mixture
  • Outlet manifold for LNP solution
  • Back-seal washing system
  • The frame (stainless steel system 1.4301)
  • Installation & familiarization by KNAUER

In addition, we offer for our customers:

  • Customized Technical documentation which is order- and article-related
  • Customer Service before, during, and after the setup
  • Capillary customization and labeling
  • FAT (Factory Acceptance Test at KNAUER Berlin)
  • SAT (Site Acceptance Test at customer site)


The skid-based NanoProducer units like the one shown require sophisticated craftsmenship and know-how. That's why they are exclusively designed, certified & distributed only directly by KNAUER Germany. The same applies for the offered additional services.



Key Features

Technical Data

Impingement Jets Mixing System Details

Fields of applications LNP production
Number of impingement jets mixers up to 8
Number of pumps up to 16
Number of flow meters up to 16
Process connection inlet Sanitary Clamp Connector (2 Inlets)
Process connection outlet Sanitary Clamp Connector (1 Outlet)
Volumetric flow rate (L/min) depending on configuration
Volumetric flow rate (L/hour) depending on configuration
Maximum operation pressure 50-70 bar
Liquid temperature range 4−60 °C (39.2−140 °F)
Wetted materials stainless steel, PEEK, Titanium, FFKM, PTFE, GFP (graphite fiber reinforced PTFE), aluminum oxide (Al2O3), ruby, sapphire
Software not included, necessary interfaces for the integration into PLC available
Interfaces Pump: LAN, RS-232, pin header connectors;
Flow meter: RS-232 + Industrial Interfaces;
Valve drive: LAN
Power supply Pump: 100–240 V, 50–60 Hz;
Flow meter: +15…24 V DC,
Maximum power consumption Values per device
Pump: maximum 320 W;
Flow meter: 3 W
Ambient conditions Temperature range: 4–40 °C; 39.2–104 °F; below 90 % humidity (non condensing)
Dimensions depending on configuration
Weight depending on configuration
API-predilution and quenching depending on configuration
GMP-ready documentation Yes
Factory acceptance test Yes
Site acceptance test Yes
Purchase order lead time minimum 5 months, depending on customer requirements
Disclaimer Depending on the process the end user must consider the legal situation of patents and intellectual property. KNAUER is designing the customized hardware solution on customers request

Documents and more information

Certified Quality 

KNAUER is known for the quality of its products and has been certified several times. We produce high-tech laboratory instruments for research, routine analysis and production.
See all Quality certificates

In addition, we have extended documentation about all our products, including CE Declarations of Conformity.
See all CE Declarations of conformity

Innovation and quality - since 1962. Made in Germany.

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Technical data or prices are subject to change without notice. Prices may vary by country and do not include taxes, customs duties or delivery. All trademarks are the property of their respective owners.Our general terms and conditions apply: www.knauer.net/terms

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