Autosampler AZURA AS 6.1L Contact us
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Article No.: AAA41AA
Articlename: Autosampler AS 6.1L

Tempered Autosampler for preparative LC

preparative HPLC autosampler with sample cooling/heating

The Autosampler

AS 6.1L can inject from up to 768 positions when equipped with microtiter plates (either high or low formats) or from up to 108 standard 1.5 ml sample vials. Sample carryover is significantly minimized thanks to a highly-effective interior and exterior needle wash procedure. This autosampler is also fast and flexible: one complete sample injection cycle takes less than one minute, including needle wash. Three different injection modes are supported; “full loop filling” (highest precision and reproducibility), “partial loop filling” (variable volumes, e.g. for dilution series) and “µl pickup” (loss-free injection of extremely small sample volumes), allowing the user to optimize sample usage. The headspace pressure function prevents bubbles from forming in the vial during sample uptake. Precolumn derivatization is supported. Preparative version for sample volumes up to 10 ml with sample tray cooling (4 - 40°C).

Key Features

Technical Data

Sample injection

Autosampler Flow Path Preparative
Maximum back pressure 350 bar
Vial/plate dimensions well plate dimensions according to ANSI SLAS 4-2004 (formerly ANSI/SBS 4-2004)
max. plate/vial height: 47 mm (incl. septa or capmat)
Injection volume range 1 µl–10 ml depending on sample loop
Sample loop 10 ml
Dispenser syringe 2500 µl
Headspace pressure built-in compressor, only for sample vials with septum
Switching time inj. valve < 100 ms
Piercing needle precision ± 0.6 mm
Sample tray cooling 4–40 °C
Vial detection missing vial/well plate detection by sensor
Wetted materials ETFE (buffer & needle tubing), stainless steel (sample needle, valve stator), PEEK (rotor seal), Kel-F (syringe valve), glass (syringe), PTFE (tip of syringe plunger)

Analytical performance

Injection modes partial loop filling
Injection precision RSD (Rel. Standard Deviation): full loop injection: < 0.3 %, partial loop injection at volumes > 5 µl: < 0.5 %, microliter pickup injection at volumes > 5 µl: < 1.0 %
Sample carryover < 0.1 % with standard needle wash
Injections per vial max. 9 injections
Injection cycle time minimum 7 s from the same vial, 14 s from different vials;< 60 s for>100 µl sample injection in all injection modes, incl. 300 µl needle wash
Analysis time max. 9 h, 59 min, 59 s


Inputs 2 programmable TTL inputs (next injection, freeze, stop)
Outputs 1 programmable relay output (inject marker, auxiliary, alarm)
Control Ethernet (LAN)
Interfaces LAN, analog

Technical parameters

Ambient conditions temperature range: 10–40 °C; 50–104 °F air humidity: 20–80%


Power supply 95–240 V AC
Dimensions 364 x 379 x 623 mm (W x H x D)
Weight 32 kg

Documents and more information

Certified Quality 

KNAUER is known for the quality of its products and has been certified several times. We produce high-tech laboratory instruments for research, routine analysis and production.
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In addition, we have extended documentation about all our products, including CE Declarations of Conformity.
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