KNAUER ClarityChrom® is a powerful, yet easy-to-use chromatography software for instrument control, data acquisition and data processing. ClarityChrom is designed for smaller laboratories. It is an economical solution compared to other more complex chromatography software while offering the full functionality of a full-featured CDS and comes also with FDA 21 CFR Part 11 compliance. ClarityChrom includes the following functionality:
• complete LC control and autosampler control package
• support for a wide range of instruments,
• scalable from 1 to 4 LC systems (instruments),
• up to 12 detectors (channels) for a system can be configured
• optional extensions, e.g. for PDA data handling, GPC analysis, SST for automated system tests, LC/MS or GC control
• included preparative functionality
• advanced, flexible preparative functionality from KNAUER with Knauer FRC control module
Please refer to the instrument support list for a detailed list of supported instruments. Beside all KNAUER instruments, devices and systems from more than 45 manufacturers can be controlled. Additionally, data acquisition can also be performed with any detector providing a voltage output by simply connecting a KNAUER IFU 2.1 interface box or any other supported A/D converter.
The system suitability test (SST) extension offers specific calculated parameters of the separation to be monitored and compared to user set limit values to evaluate the reproducibility of the results of the entire chromatography system. The parameters, available for check, are retention time, area, height, amount, width at half peak height, asymmetry, symmetry/tailing, capacity, efficiency, efficiency/column length, HETP, resolution and response. Calculations are possible from all or just selected validated (calibrated) components.
The PDA extension allows to acquire and process 3D data from a photo diode array detector (KNAUER PDA detectors are fully supported). The PDA extension provides peak purity analysis and peak identification by spectral library search in self-made or commercial spectra libraries. Signals from a desired wave length can be easily added from the 3D data.
The SEC/GPC option provides interactive and automated gel permeation chromatography analysis, including re-calibration and GPC reporting, as well as simplifies the retrieval of GPC data. Narrow or broad standard calibration methods are supported combined with flow rate correction and universal calibration. In chromatogram view the molecular weight and cumulative molecular weight distribution can be easily compared by chromatogram overlay. The GPC results table displays molecular weight averages together with peak details for active signal.
Clarity Chrom offers all the necessary operations for an analytical lab. The fractionation functionality along with drivers for some fraction collectors allow for simple fractionation tasks.
Moreover, the KNAUER-exclusive Knauer FRC control module adds more fractionation options to this feature list and more drivers for fraction collectors; this allows more flexibility in the lab. During the run, fractions can be collected manually via software; this includes the information about the collected peaks from the chromatogram. The KNAUER MultiValve fraction collector supports KNAUER electrical valves as fraction collector. This allows a practical unlimited fraction volume because there is no defined vial volume, depending from the used rack, as for other fraction collectors. Up to 32 KNAUER electrical valves can be cascaded as a fraction collector. With a supported mass spectrometer, mass-triggered fractionation is possible. The rack view shows the volume and retentions time of all collected fractions. Due to the included links, the matching chromatogram for each fraction can be easily opened directly from the rack view.
ClarityChrom is the best solution for all laboratories searching for an up-to-date and robust software with support of devices from many manufacturers to be flexible in instrumentation but also meet the requirements for modern laboratories.