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Based on ultra-high purity silica, the Eurospher II Chiral column materials are characterized by high enantioselectivity and loadability.
Available in a wide range of dimensions for analytical, preparative and SMB (simulated moving bed) applications, Eurospher II Chiral columns are the perfect choice for even the most challenging enantioseparation tasks

Since chiral separations are not very well predictable, KNAUER offers a chiral screening service for your samples. 

Depending on the analytes, three different chiral selectors are available:

Chiral column HPLC mode USP code Description Chiral selector
Chiral AM NP L51 polysaccharide chiral stationary phase Amylose-tris-(3,5-dimethylphenylcarbamate)
Chiral AM-R RP L51 polysaccharide chiral stationary phase Amylose-tris-(3,5-dimethylphenylcarbamate)
Chiral OM NP L40 polysaccharide chiral stationary phase Cellulose-tris-(3,5-dimethylphenylcarbamate)
Chiral OM-R RP L93 polysaccharide chiral stationary phase Cellulose-tris-(3,5-dimethylphenylcarbamate)
Chiral NR NP n/a immobilized brush-type phase p-electron donor- and p-electron acceptor groups
Chiral NR-R RP n/a immobilized brush-type phase p-electron donor- and p-electron acceptor groups


Characteristics of chiral separations

The following table gives an overview of the differences between the three different Eurospher II Chiral phases.

Eurospher II Chiral NR Eurospher II Chiral OM Eurospher II Chiral AM
Analytes need an oxygen at or near the chiral center and additionally an aromatic ring Highly versatile chiral phase Highest generality of all Eurospher II Chiral phases
Elution more predictable than with Chiral AM and OM phases Analyte does not need to carry an aromatic ring Analyte does not need to carry an aromatic ring
Inversion of elution order is possible No inversion of elution order possible No inversion of elution order possible
Very high capacity and thus ideally suited for preparative HPLC Scale up in the preparative HPLC range is possible Scale up in the preparative HPLC range is possible
Stable in all common HPLC eluents Caution! Not stable in all HPLC eluents! Caution! Not stable in all HPLC eluents!

Physical properties of chiral columns

  • Chiral AM and OM
  • Chiral NR
  • Physical properties of Eurospher II Chiral AM and OM

    Eurospher II Chiral AM is equivalent to Daicel's well-known Chiralpak AD*, and Eurospher II Chiral OM is equivalent to Chiralcel OD* phases. KNAUER offers these chiral stationary phases for two different separation modes: Eurospher II Chiral AM and Chiral OM are designed for separations in normal phase (NP) mode, Eurospher II Chiral AM-R and Chiral-OM-R for separations in reversed phase mode.

    Both Eurospher II Chiral AM and Chiral OM columns are able to separate neutral, acidic and basic racemates.

    *) Chiralpak AD and Chiralcel OD are brand names of Daicel Corporation.

    Silica gel

    ultra pure, > 99.99 %

    Metal content

    < 10 ppm

    Particle size

    3 μm, 5 μm, 10 μm

    Particle form

    spherical

    Pore size of base material

    1000 Å

    Chiral selector

    amylose-tris-(3,5-dimethylphenylcarbamate) for Chiral AM

    cellulose-tris-(3,5-dimethylphenylcarbamate) for Chiral OM

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  • Physical properties of Eurospher II Chiral NR

    Eurospher II Chiral NR is an immobilized brush-type phase with very broad generality and complementary selectivity to Eurospher II Chiral AM and OM. In many cases it is similar to Eurospher II Chiral AM or Chiral OM, but much more stable. The Chiral NR selector is covalently bound, so that you can use all HPLC eluents.

    Due to its high loadability it is perfectly suited for preparative separations. This CSP is offered for normal phase mode (Eurospher II Chiral NR) and for reversed-phase mode (Eurospher II Chiral NR-R).

    Eurospher II Chiral NR is similar to Daicel's immobilized Chiralpak IA, IB and IC* columns.

    *) Chiralpak IA, IB and IC are brand names of Daicel Corporation

    Silica gel

    ultra pure, > 99.99 %

    Metal content

    < 10 ppm

    Particle size

    Eurospher II Chiral NR: 3 μm, 5 μm, 8 µm, 12 µm

    Eurospher II Chiral NR-R:  8 µm, 12 µm

    Particle form

    spherical

    Pore size of base material

    100 Å

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chiral screening service

  • Unsure which Eurospher II Chiral column to choose for your separation task?

    KNAUER offers a chiral screening service for your samples. We will find the best suited column for you!
    This service is free of charge. For more information, click below.

    Chiral Screening Service

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