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Based on ultra-high purity silica, the Eurospher II Chiral column materials are characterized by high enantioselectivity and loadability.
Available in a wide range of dimensions for analytical, preparative and SMB (simulated moving bed) applications, Eurospher II Chiral columns are the perfect choice for even the most challenging enantioseparation tasks

Since chiral separations are not very well predictable, KNAUER offers a chiral screening service for your samples. 

Depending on the analytes, three different chiral selectors are available:

Chiral column HPLC mode USP code Description Chiral selector
Chiral AM NP L51 polysaccharide chiral stationary phase Amylose-tris-(3,5-dimethylphenylcarbamate)
Chiral AM-R RP L51 polysaccharide chiral stationary phase Amylose-tris-(3,5-dimethylphenylcarbamate)
Chiral OM NP L40 polysaccharide chiral stationary phase Cellulose-tris-(3,5-dimethylphenylcarbamate)
Chiral OM-R RP L93 polysaccharide chiral stationary phase Cellulose-tris-(3,5-dimethylphenylcarbamate)
Chiral NR NP n/a immobilized brush-type phase p-electron donor- and p-electron acceptor groups
Chiral NR-R RP n/a immobilized brush-type phase p-electron donor- and p-electron acceptor groups


Characteristics of chiral separations

The following table gives an overview of the differences between the three different Eurospher II Chiral phases.

Eurospher II Chiral NR Eurospher II Chiral OM Eurospher II Chiral AM
Analytes need an oxygen at or near the chiral center and additionally an aromatic ring Highly versatile chiral phase Highest generality of all Eurospher II Chiral phases
Elution more predictable than with Chiral AM and OM phases Analyte does not need to carry an aromatic ring Analyte does not need to carry an aromatic ring
Inversion of elution order is possible No inversion of elution order possible No inversion of elution order possible
Very high capacity and thus ideally suited for preparative HPLC Scale up in the preparative HPLC range is possible Scale up in the preparative HPLC range is possible
Stable in all common HPLC eluents Caution! Not stable in all HPLC eluents! Caution! Not stable in all HPLC eluents!

Physical properties of chiral columns

chiral screening service

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