The ability to measure the serum concentrations of antiepileptic drugs, and the widespread use of this procedure, has markedly improved the treatment given to patients with epilepsy during the past 3 decades. The monitoring of antiepileptic drug concentrations in serum is necessary for the optimal drug therapy of seizures, because the therapeutic and toxic effects of these drugs are better related to serum concentration than to administered dosage. In this Application Note can you see a separation of 11 Substances of Antiepileptics in serum with a HPLC method.
1. PEMA; 2. Ethosuximide; 3. Primidone; 4. Carbamazepine-diol; 5. 10-OH-Carbamazepine; 6. Phenobarbital; 7. Carbamazepine-epoxide; 8. Oxcarbazepine; 9. Internal Standard (IS); 10. DPH; 11. Carbamazepine
| Method | HPLC |
|---|
| Mode | RP |
|---|---|
| Substances | PEMA, Ethosuximide, Primidone, Carbamazepine-diol, 10-OH-Carbamazepine, Phenobarbital, Carbamazepine-epoxide, Oxcarbazepine, DPH, Carbamazepine |
| Key words | Antiepileptics, Drugs, Human serum |
| CAS number | 7206-76-0, 77-67-8, 125-33-7, 104839-39-6, 3564-73-6, 50-06-6, 36507-30-9, 28721-07-5, 7440-56-4, 58-73-1,298-46-4 |
Eurospher
Article No.: 10DE181ESJ
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