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Impingement jets mixing technology for the production of lipid nanoparticles

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Article No.: IJM-SKID
Articlename: IJM-Skid - production scale

Impingement jets mixing technology for the production of lipid nanoparticles


IJM-Skid for production scale

The IJM-Skid for LNP production contains eight parallel mixing
units. Each unit consists of two pumps to deliver lipid and API
streams, two flowmeters for flow control and one jet mixer. Predilution
of the API and quenching is performed for the combined
flow of all eight units in one process step outside the IJM-Skid. 
The number of parallel units depends on the application. Also, the
number of pumps, flowmeters, jet mixer and pipes can be adapted
to the required conditions and scale.
All skids are built in a stainless steel frame on casters and are
suitable for CIP cleaning procedure in pharmaceutical production.

  • KNAUER Highpressure dosing pumps 80P
  • Coriolis flow meters
  • KNAUER IJM-mixers
  • Inlet manifolds for Lipid solution and API
  • Outlet manifold for LNP solution
  • Frame (Stainless Steel system 1.4301) incl. cable trays
  • Technical Documentation
  • Capillary Customization and labeling
  • FAT (Factory Acceptance Test at KNAUER Berlin)
  • SAT (Site Acceptance Test at customer site)
  • Installation & familiarization by KNAUER

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