Classic HPLC methods are still frequently used today. Our question in the headline is typically asked by people responsible for analytical HPLC equipment whenever they have to replace a system.
It's really hard to predict, if a dedicated UHPLC system would be well-utilized or only rarely used in your lab, because your selection of methods will always depend on external requirements and regulations. Sounds like a dilemma.
Wouldn't it be good if you could get an advanced HPLC system today, that can be upgraded to deliver UHPLC performance when you need it?
The AZURA® 862 HPLC systems offer exactly that adaptability.
Replacing an old HPLC system with a most up-to-date AZURA 862 HPLC system, will give you high-performing components like the P 6.1L eluent supply, the flexible AS 6.1L autosampler, sensitive detectors with high data acquisition rates, and modern network connectivity today.
You can continue to run your routine applications at slightly higher performance and you will benefit from modern system features. The 862 bar pressure-resistance increases the number of modern small-particle columns applicable on your system. So, with AZURA 862 you will be able to use e.g. core-shell column materials.
The analytical HPLC systems AZURA 862 raise the bar for standard HPLC, enabling separations at up to 12,500 psi / 862 bar.
Should your future methods require higher resolution, you can then easily upgrade your AZURA 862 with ULDC technology. This upgrade transforms the system into an ultra-low dispersion chromatography system, which will minimize the extra-column volume and provide UHPLC benefits.
The separation power of modern sub-2µm or core-shell columns can be fully utilized with ULDC resulting in higher resolution for sharper peaks or faster separations.
With an HPLC->ULDC adaptable system you don't need to look for a dedicated UHPLC today, only to be safe for the future.
Run your existing HPLC methods today. Switch to highest resolution with the ULDC technology upgrade when you need it to make full use of modern small particle columns and methods.
The upgradeability is not only practical from an investment perspective, but also more sustainable, because no systems will sit around unused, just due to an unexpected need for HPLC or UHPLC methods.