Purification of cannabidiol from CBD oil by preparative HPLC

The demand of pure cannabidiol (CBD) is increasing and therefore methods are needed that allow purification of CBD in high purity from different kind of samples i.e. cannabis extract, paste or oil. Preparative HPLC is a well-established method for purification of target substances from natural substrates in high purities and was therefore applied for this task. In this application a preparative HPLC method was developed for purification of CBD from a commercial CBD rich oil. CBD was purified with high purity and recovery thus increasing the purity from 71.6% to 94.5%.

Methode	HPLC
Modus	RP
Substanzen	Cannabinoids
Schlüsselwörter	Cannabis, hemp, purification, scale-up, preparative LC, CBD purification, CBDV, CBG, CBD, CBN, Δ9-THC, CBL, CBC
CAS Nummer	24274-48-4, 2808-33-5, 13956-29-1, 521-35-7, 1972-08-3, 21366-63-2, 20675-51-8
Version	Version 1 I 08/2020