AZURA® Prep HPLC Lab System
With a maximum flow rate of 50 ml/min
Up to 200 bar
Sample injections via valve, easily expandable with a sample pump
suitable for 4–20 mm column ID
UV/VIS detector with one variable wavelength
Binary high-pressure gradient
Discover the AZURA Prep HPLC Lab System, the ultimate solution for your preparative separations! With its customizable and flexible components, you can create an LC system that meets your specific needs. Discover our brochure
Flexible selection of detector types: UV/VIS (VWD, MWD, DAD), RID, FLD, and ELSD
Reliable fraction collection of large volumes or numerous fractions
Enhanced preparative LC software including direct control and functional visualization
GMP-ready solution:
21 CFR part 11 and GAMP 5 compliant software, certificates for product-wetted parts of the system
Popular Add-ons: sample pump, column selection valve, eluent heater
Your idea – Our solution!
For your purification workflow of peptides, oligonucleotides, RNA, cannabinoids and many other compounds.
The AZURA Prep HPLC Lab System offers outstanding gradient performance and ease of use thanks to its compact design and user-friendly PurityChrom 6 software.
A streamlined configuration enables a cost- and space-efficient preparative HPLC solution. However, the system can be upgraded with whatever modules your workflow needs to perform ideal, e.g.:
- eluent/column heater for working at evelated temperatures
- sample pump
- column-selection valve
- additional detectors
- fractionation valve for collecting high-volume frations
Solvent Selection and Delivery
Precise and reliable pumps covering a wide flow range for various gradient and solvent selection options. The AZURA semi-preparative pump P 6.1L with 50 ml pump head is available as an isocratic or binary HPG pump. It is made for medium-size purification tasks and up-scaling processes. The preparative HPLC pump AZURA P 2.1L covers a wide flow rate and pressure range. It has been designed for the purification of milligram to gram samples. The integrated automatic RFID pump head recognition allows a quick adaptation to various applications.
Adapt the sample injection mode to your preparative task
Manual or automated injection: Use a valve or a valve with feed pump for feed injection. Sample injection can be easily automated using AS 6.1L autosampler, which can inject up to 10 ml per injection, or with the LH 2.1 Liquid Handler that combines autosampler functionality with fraction collector functionalities.
Select your preferred injection option:
- Manual or automated injection valve with sample loop or Variloop up to 40 ml sample
- Sample pump for large sample volumes
- Autosampler or Liquid Handler for increased throughput
The KNAUER VariLoops are the perfect solution for the injection of medium up to high sample volumes (up to 40 ml). The sample loop can be emptied completely or partially as well as filled completely or partially. This allows you to work very flexible and easily switch between different sample sizes while keeping constant and reproducible injection volumes for every sample size.
Column Switching
Switching valves are ideal for screening and scale-up. They can be easily integrated into your system at pressures up to 400 bar and maximum flow rates of 300 ml/min. Up to 16 columns can be selected.
Temperature Control
Increase performance. Minimize solvent viscosity. When performing preparative HPLC at temperatures above 40°C in air-conditioned laboratories e.g. in RNA purification processes, a uniform temperature distribution is essential.
In addition to column temperature control via a column oven or heating sleeve, precise eluent temperature management can be critical to process performance. The AZURA Eluent Heater ELH 2.1L or pump head heating sleeves help prevent temperature gradients across the column by maintaining a stable and uniform temperature throughout the system.
Detection options
KNAUER gives you the opportunity to analyze nearly every compound due to a large portfolio of HPLC detectors. For the achievement of your analysis goals and for matching your separation scale, our detectors are flexible in the setup,
including flow cells and fiber optics. Our product line of UV/VIS detectors ranges from single variable wavelength to combination detectors for simultaneous measurement of UV/VIS, conductivity and pH, and to even 8-channel diode array detectors with 3D scan capability.
Further detector options inlcude:
- AZURA® RID 2.1L HighFlow
- Fluorescence Detector
- Light Scattering Detector
- Conductivity/pH Monitor
Your preferred detection method is not listed? Please do not hesitate to contact us. We will be happy to advise you on additional options.
Select from an impressive range of easily exchangeable preparative and semi-preparative flow cells for UV/VIS and DAD detectors. With capillary connections ranging from 1/16” to 1/4’’ and TRI-Clamp adaptions, optional fiber optics technology and a variety of flow cell wetted materials, a wide spectrum of applications can be covered. KNAUER´s patented CombiLight flow cells allow the simultaneous measurement of UV/VIS, conductivity and eluent temperatur.
Fiber optic cables offer the possibility to separate the flow cell from the detector. This enables demanding applications such as measuring directly after a heated LC column or in hazardous environments, allowing safe operation of the instrument while maintaining performance.
Collect large quantities or large numbers of fractions
KNAUER offers different valves for fraction collection and variations of trusted fraction collectors. Whether you are doing research and development or production, there is an appropriate solution.
- KNAUER Fraction Collector FC6.1: Entry level fractionation option
- LABOCOL Vario 4000 / Plus: Versatile fractionation at higher flow rates
- Liquid Handler LH2.1: Automating preparative separations with highest flexibility and throughput
- Fractionation valves: Fraction collection of large volumes
Software Solutions
KNAUER offers various chromatography software solutions to meet your requirements. Our software packages are designed to deal with different levels of complexity and laboratory size. The well-known software solutions work with KNAUER instruments, but can be combined with a variety of other instruments. Do not hesitate to ask for details. All of these solutions are also available with preparative functionality to enable chromatography purification tasks. You will find this option implemented so consistently only at KNAUER.
- PurityChrom® 6
- Mobile Control (Chrom)
- ClarityChrom® CDS
- OpenLab
- Chromeleon™
Most flexible system solutions on the market
Configure your perfect preparative HPLC system according to your needs.
