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AZURA® SMB Pilot Systems

Maximize throughput – Purify at kilogram scale up to 400 ml/min

Column compatibility:

Use columns up to 100 mm ID  

AZURA® SMB Pilot System

Software

21 CFR Part 11 compliant

Customizable

Add detectors and heating options

AZURA® SMB Pilot Systems

This AZURA SMB pilot systems are dedicated for the continuous production of API‘s. View our brochure

AZURA® SMB Pilot System Infographic

Smooth transition from lab to process with AZURA SMB Pilot systems

To extract high-purity pharmaceutical active ingredients from natural products at high yields is a major challenge. This also applies to the cannabinoid sector. Simulated Moving Bed (SMB) chromatography, as a continuous LC method, sets the standard for productivity, purity and yield.

This AZURA SMB pilot system is dedicated for the continuous production of API´s. The System allows the continuous separation of mixtures of substances and extraction into two fractions. High purities and simultaneous yields of up to 100% distinguish this process from conventional preparative LC methods. 

The system features four preparative Pump BlueShadow 80P, four CORI-Flow M14 flowmeters and seven multi-position valves integrated into four AZURA Assistans ASM 2.2L

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AZURA® SMB Pilot

High-Precision Pumps:
Three stainless steel pumps with 500 ml/min heads deliver up to 250 ml/min in the SMB cycle. A 100 ml feed pump ensures accurate low-flow dosing.

Intelligent Valve Control:
Seven stainless steel multi-position valves (1/8" connections) are managed by the Valve Unifier VU 4.1, featuring RFID-based valve recognition, torque/speed adjustment, and automated GLP maintenance alerts.

Service-Friendly Modular Design:
The ASM 2.2L enables fast module replacement via four screws—ideal for minimizing system downtime in production settings.


Powerful Control Software:
PurityChrom® MCC offers intuitive operation, complete data logging (UV, RI, flow, analog signals), and is 21 CFR Part 11 compliant.

Comprehensive Flow Monitoring:
Four integrated flowmeters provide real-time accuracy across all SMB zones and the feed, enabling immediate detection and correction of deviations.

Production-Optimized System Design:
Delivered pre-installed on a mobile stainless-steel frame (1465 × 785 × 1200 mm) with structured tubing, external access ports, and hygienic design for easy cleaning and site transfer.

AZURA® SMB Pilot – High Flow

High-Performance Pumps:
Three stainless steel pumps with 1000 ml/min heads allow flow rates up to 400 ml/min in the SMB cycle. A separate 250 ml feed pump enables precise low-flow dosing.

Modular & Service-Friendly Design:
The ASM 2.2L allows tool-free module replacement by removing just four screws—ideal for minimizing downtime in production.

Advanced Software Control:
PurityChrom® MCC enables intuitive operation, full data logging (incl. UV, RI, flowmeters), error handling, and is 21 CFR Part 11 compliant.


Full Process Monitoring:
Four integrated flowmeters ensure accurate real-time monitoring across all SMB zones and the feed, allowing immediate response to flow deviations.

Production-Ready System Design:
Pre-installed on a mobile stainless-steel table (1465 × 785 × 1200 mm) with fixed tubing, accessible ports, leak trays, and antistatic wheels for easy cleaning and transport between production sites.

Upgrade Kit

With our pre-configured Upgrade Kits, you can easily enhance your SMB chromatography system and customize it to meet your specific needs.

Precise Monitoring of the SMB Cycle with Detectors:

  • Refractive index detector – Suitable for alcohols, sugars, lipids, and more.
  • Compact UV detector – Supports a wide range of flow cells; also available as a remote flow cell variant.
  • Conductivity monitor – Features a biocompatible flow cell for flow rates up to 100 ml/min.


Heating and Column Organization:

  • Oven for AZURA® SMB Lab – Heats up to eight KNAUER columns (max. 250 × 50 mm inner dimension) to temperatures up to 80°C.
  • Column holder – Accommodates up to eight SMB columns (max. 250 × 50 mm).

AZURA SMB Pilot

  • The three system pumps are equipped with 500 ml/min stainless steel pump heads, enabling volume flows of up to 250 ml/min inside the SMB cycle. The feed pump works with a 100 ml pump head and can thus also precisely dose the feed in the low flow range.

 

  • The seven multi-position valves, operated by the valve unifier VU 4.1, are made of stainless steel and are equipped with connections for 1/8" pipes. The Valve Unifier VU 4.1, integrated in the ASM 2.2L provides the newest technology to our SMB systems. The smart valve drive features automatic valve recognition and adjusts torque and switching speed specifically for each valve. This RFID technology enables to read GLP data, for example the maintenance of the rotor seal exchange is simplified by automatic notifications.

 

  • The new plug-in design of the ASM 2.2L allows the modules to be removed by loosening just four screws, enabling the user to quickly exchange the modules. Especially in production processes the downtime of a system in case of service needs to be minimized.

 

  • The PurityChrom® MCC control software provides an intuitive and easy operating of the SMB. PurityChrom® MCC offers the possibility to independently record, store, monitor, and process error messages, warnings of level meter as well as several detector signals (UV, RI), flowmeters and other signals via analog inputs. The software complies with 21 CFR Part 11.

 

  • The Pilot SMB system includes four flowmeters. Flow rate accuracy in all SMB zones and the feed stream is recorded for each cycle. The use of four flowmeters allows a complete real-time monitoring of the entire SMB process so that the user can directly react to deviations of the flow rates.

 

  • As a complete system, the AZURA SMB pilot system will be pre-installed on a table with the dimensions 1465 x 785 x 1200 mm  (WxDxH). Every device and capillaries are fixed and therefor well structured. Additional components i.e. flowmeters are also integrable. The product streams and the column in and outlets are placed user friendly outside the table ensuring a fast and easy connection via tube fittings. The easy cleanable stainless-steel surface, antistatic wheels and leakage tubs fulfils main requirements for production areas. The AZURA SMB Pilot System can be easily transferred by the customer inside or between different production sides due to the moveable design. 



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