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Are all solvents miscible with each other?

Miscibility chart

Not all solvents are miscible. If you are unsure about the miscibility, then try mixing in a vessel before using the HPLC instrument. The shown miscibility chart is also a helpful tool. (white = miscible, black = immiscible) Example: acetonitrile and water are miscible, but mixing acetonitrile with hexane will not work.

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