Why does a mass spectrometer (MS) need an ion source?

In a mass spectrometer, the analytes are separated as charged molecules (in some cases also fragments / aggregates) in an electric field. They need to be introduced in the gaseous state. The "gas" has to be very highly diluted so that the ions can be analyzed on individual trajectories. Otherwise collisions with other ions could happen, thereby passing their charge forming hybrids or influencing the trajectories of each other. Coupled to an HPLC system, the ion source must be able to separate and ionize the analytes as effectively as possible from the vast excess of eluent / solvent, so that the ions can be analyzed in the quadrupole.

Documents and more information

We separate molecules and unite people.

Based in Berlin, KNAUER has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography systems and components, including:

Analytical HPLC / UHPLC
Preparative HPLC
Fast protein liquid chromatography (FPLC)
Multi-Column Chromatography / SMB

We are an established partner in science. Today and in the future.​​​​​​

Do you need more information?

Please contact us!

Follow us