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What is the difference between UHPLC and HPLC columns?

The main difference is the size of used particles filled into the column. Particle sizes ≤ 2 µm are commonly used for UHPLC. Particles with a size of 3 µm up to 5 µm are usual for classical analytical HPLC.
Furthermore the column inner diameter is varying. KNAUER UHPLC columns come with an inner diameter of 2 mm. Columns with an inner diameter 3 mm - 4,6 mm are analytical HPLC columns.

We separate molecules and unite people.

Based in Berlin, KNAUER has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography systems and components, including:

Analytical HPLC / UHPLC
Preparative HPLC
Fast protein liquid chromatography (FPLC)
Multi-Column Chromatography / SMB
Osmometry

We are an established partner in science. Today and in the future.​​​​​​

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