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What is the difference between batch chromatography and SMB?

Batch chromatography (single-column) SMB chromatography (multi-column)
   
Unlimited number of fractions Two fractions, no waste
Recovery typically below 80 % Recovery up to 100 %
EITHER high purity OR high yield High purity AND high yield
Isocratic or gradient Isocratic (step gradient possible)
High solvent consumption Can be as low as 10 % of batch consumption Very diluted product Product concentration comparable with input concentration (feed)

 

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