What is the difference between batch chromatography and SMB?

Batch chromatography (single-column) SMB chromatography (multi-column)
Unlimited number of fractions Two fractions, no waste
Recovery typically below 80 % Recovery up to 100 %
EITHER high purity OR high yield High purity AND high yield
Isocratic or gradient Isocratic (step gradient possible)
High solvent consumption Can be as low as 10 % of batch consumption Very diluted product Product concentration comparable with input concentration (feed)


Documents and more information

We separate molecules and unite people.

Based in Berlin, KNAUER has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography systems and components, including:

Analytical HPLC / UHPLC
Preparative HPLC
Fast protein liquid chromatography (FPLC)
Multi-Column Chromatography / SMB

We are an established partner in science. Today and in the future.​​​​​​

Do you need more information?

Please contact us!

Follow us