During the development of a SMB method, it is helpful to determine the concentration profiles in the four SMB zones. An inline sampling was established in addition to the sampling at the extract and raffinate outlet. Therefore, a manual injection valve was implemented as sampling valve before the inlet of column 1 in the AZURA lab SMB system. With this setup a separation method of paracetamol and caffeine was optimized, and samples were taken in all four zones. The resulting concentration profiles help optimizing the method.
|Method||Simulated Moving Bed chromatography|
|Key words||Simulated moving bed, SMB, inline sampling, caffeine, paracetamol,|
|CAS number||Paracetamol: CAS 103-90-2; Caffeine: CAS 58-08-2|
|Version||1 / 12-2020|
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