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Determining molecular weights for P(D,L)LA in THF – an internal validation

Application No.: VEV0087

Determining molecular weights for P(D,L)LA in THF – an internal validation

A method was validated intralaboratory to analyze low molecular weight P(D,L)LA (polylactic acid) in tetrahydrofuran (THF) with respect to the number average molar mass (Mn) and weight average molar mass (Mw). For this purpose, a KNAUER HPLC system was used in combination with a linear GPC column. The obtained molar masses were compared with the values of the absolute methods and any deviations were discussed. The method was validated with respect to its repeatability and robustness to changes in flow rate, temperature, injection volume and sample concentration.

Technical Data

Application details

Method HPLC
Mode GPC
Substances polylactide, polylactic acid
Key words PLA, polylactide, polylactic acid, GPC, SEC, polymer, biopolymers, bioplastic, biodegradable, universal calibration, PS, polystyrene, PMMA, green SEC, green GPC, biobased plastic, validation
Version Version 1/ 11/2021

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