A method for the analysis of low molecular weight P(D,L)LA by GPC with respect to its number average molar mass (Mn) and weight average molar mass (Mw) was validated intralaboratory. To achieve this a KNAUER HPLC system was used in combination with a linear GPC column. The obtained molar masses were compared with the values from the absolute methods and deviations were discussed. The method was validated with respect to its repeatability and robustness to changes in flow rate, temperature, injection volume and sample concentration.
10-point PMMA universal calibration in EtOAc
Mn (dots) and Mw (squares) values at 0.1-, 0.2-, 0.3-, 0.5-, 1.0-, 2.0-, and 3.0 mg/ml sample concentration. Triple determination with relative standard deviation
|Key words||PLA, polylacitde acid, GPC, SEC, polymer, biopolymers, bioplastic, biodegradable, universal calibration, PS, polystyrene, PMMA, green SEC, green GPC, biobased plastic, validation|
|Version||Version 1/ 11/2021|
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