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Determining molecular weights for P(D,L)LA in ethyl acetate – an internal validation

Applikationsnr.: VEV0086

Determining molecular weights for P(D,L)LA in ethyl acetate – an internal validation

A method for the analysis of low molecular weight P(D,L)LA by GPC with respect to its number average molar mass (Mn) and weight average molar mass (Mw) was validated intralaboratory. To achieve this a KNAUER HPLC system was used in combination with a linear GPC column. The obtained molar masses were compared with the values from the absolute methods and deviations were discussed. The method was validated with respect to its repeatability and robustness to changes in flow rate, temperature, injection volume and sample concentration.

  • 10-point PMMA universal calibration in EtOAc

  • Mn (dots) and Mw (squares) values at 0.1-, 0.2-, 0.3-, 0.5-, 1.0-, 2.0-, and 3.0 mg/ml sample concentration. Triple determination with relative standard deviation

Technische Daten

Spezifikationen

Methode HPLC
Modus GPC
Substanzen polylactide acid
Schlüsselwörter PLA, polylacitde acid, GPC, SEC, polymer, biopolymers, bioplastic, biodegradable, universal calibration, PS, polystyrene, PMMA, green SEC, green GPC, biobased plastic, validation
Version Version 1/ 11/2021

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