Eurocel chiral columns: your reliable partner for chiral separations
The Eurocel line of chiral stationary phases (CSP) was designed to tackle a wide range of chiral separation tasks. Based on a premium quality silica gel matrix coated with a derivatized cellulose poysaccharide, the Eurocel chiral column materials are characterized by an extremely high enantioselectivity and loadability.
Eluent flexibililty
While other CSPs are typically used in normal phase mode only, Eurocel columns can be used in normal phase mode, reversed phase mode and polar organic mode, without any loss in selectivity. Switching between different eluent types requires only short equilibration times.
Physical properties of Eurocel
Silica gel | ultra pure, 3rd generation |
Particle size | 3 μm, 5 μm, 10 μm, 20 μm |
Particle form | spherical |
Pore size | 1000 Å |
Polysaccharide form | derivatized cellulose, coated |
Modification (chiral selector) | Eurocel 01: 3,5-dimethylphenylcarbamate |
Available in a wide range of dimensions for analytical, preparative, simulated moving bed and supercritical fluid applications, Eurocel columns are the perfect choice for even the most challenging enantioseparation tasks.
Stability of Eurocel
Eurocel chiral columns exhibit exceptionally robust performance for large numbers of injections. Eurocel CSPs also feature a particularly narrow particle size and pore size distribution, as well as outstanding mechanical stability with a pressure limit of 300 bar.
Eluent modifiers such as mineral and organic acids, buffer salts or amines over a pH range from 2 to 8 can be used with all Eurocel columns.
High loadability
Eurocel chiral columns offer high loadability for easy and cost effective upscaling.
Selectivities
The available Eurocel chiral columns offer a proven set of different selectivies, allowing for separations of a wide range of chiral compounds. With all Eurocel chiral materials providing great eluent flexiblility, high loadability, and exceptional stability the process of method development can be substantially simplified.
CSP | Polysaccharide | Modification (R=...) | Application |
|---|---|---|---|
Eurocel 03 |
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| aryl methyl esters, |
Eurocel 02 |
|
| small aliphatic and |
Eurocel 01 |
|
| alkaloids, tropines, |
Eurocel 04 |
|
| cyclopentenones |
Derivatization of the cellulose OH-groups creates supramolecular helical polymer structures, combining polar and π-π interactions with inclusion complexation resulting in potent selectivity.
Eurocel stationary phases are particularly enantioselective for organic and organometallic species. The peak elution order will depend on the Eurocel modification used and the physicochemical properties of the eluting substance.
To be sure you get the most suitable Eurocel column for your application, we recommend that you take advantage of our free column screening service by submitting a sample of your analyte.
Range of applications
Eurocel chiral columns are typically used for separations of
- pharmaceutical active compounds
- chiral compounds in foodstuffs, dyes, preservatives
- chiral catalysts and bioorganic racemates
Handling guidelines for Eurocel
Eurocel columns are compatible with most typical HPLC solvents. As with any CSP based on modified cellulose, some HPLC solvents can damage this type of column, even when in low concentrations. To ensure optimal performance, detailed column handling guidelines are provided with every column. When switching eluent types, an appropriate solvent intermediate such as 2-propanol is recommended to achieve short equilibration times.
Temperature is also a very important parameter for chiral separations. Eurocel columns can be operated reproducibly between 4 and 40 °C. In general, lower column temperatures will improve enantioselectivity.
Click here for a list of all available Eurocel columns
Your contact
Downloads
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Columns: Eurocel brochure | (631 KB) |
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Columns: Eurocel FAQs | (76 KB) |
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Columns: Chiral screening data sheet | (39 KB) |
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Columns: Eurocel care and use | (122 KB) |
