1. 4-Aminophenol; 2. Paracetamol; 3. N-(4-hydroxyphenyl)propanamide; 4. N-(2-hydroxyphenyl)acetamide; 5. N-(3-chloro-4-hydroxyphenyl)acetamide; 6. 1-(4-Hydroxyphenyl)ethanoneoxime; 7. N-phenylacetamide; 8. 4-(Acetylamino)phenyl acetate; 9. 4-Nitrophenol; 10. Chloroacetanilide; 11. 1-(2-Hydroxyphenyl)ethanone
Separation of paracetamol and common synthesis impurities
Article number: VPH0003J
| Method | UHPLC |
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| Eluent | A: 1.7 mM NaH2PO4, pH 3.7 B: Acetonitrile
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| Gradient | 0.0 – 0.3 min 13 % B 0.3 – 2 min 13 – 70 % B 2 – 2.5 min 70 % B
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| Flow rate | 0.85 ml/min |
| Mode | RP-Mode |
| Injection volume | 1 µl |
| Pressure | 950 bar (13800 psi) |
| Temperature | 50 °C |
| Detection | MW-1, 254 nm (100 Hz, 0.005 s) 10 mm, 2 µl flow cell
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| Chromatogram | 1. 4-Aminophenol 2. Paracetamol 3. N-(4-hydroxyphenyl)propanamide 4. N-(2-hydroxyphenyl)acetamide 5. N-(3-chloro-4-hydroxyphenyl)acetamide 6. 1-(4-Hydroxyphenyl)ethanoneoxime 7. N-phenylacetamide 8. 4-(Acetylamino)phenyl acetate 9. 4-Nitrophenol 10. Chloroacetanilide 11. 1-(2-Hydroxyphenyl)ethanone
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Chromatogram VPH0003J | 1. 4-Aminophenol; 2. Paracetamol; 3. N-(4-hydroxyphenyl)propanamide; 4. N-(2-hydroxyphenyl)acetamide; 5. N-(3-chloro-4-hydroxyphenyl)acetamide; 6. 1-(4-Hydroxyphenyl)ethanoneoxime; 7. N-phenylacetamide; 8. 4-(Acetylamino)phenyl acetate; 9. 4-Nitrophenol; 10. Chloroacetanilide; 11. 1-(2-Hydroxyphenyl)ethanone |
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Vertex Plus Column 100 x 2 mm BlueOrchid 175-1.8 C18 | 10BI181BOE | Vertex Plus Column 100 x 2 mm BlueOrchid 175-1.8 C18 |
Technical data are subject to change without notice.